An unusual bisnor-clerodane diterpenoid from Polyalthia simiarum.
Nat Prod Commun
; 5(10): 1543-6, 2010 Oct.
Article
en En
| MEDLINE
| ID: mdl-21121244
ABSTRACT
The stem bark of Polyalthia simiarum has yielded a new bisnor-type clerodane diterpenoid, 2-oxo-14,15-bisnor-3,11E-kolavadien-13-one (1), and three previously known clerodane derivatives, kolavenic acid (2), 16beta-hydroxycleroda-3,13(14)Z-dien-15,16-olide (3), and 16-oxocleroda-3,13(14)E-dien-15-oic acid (4). The structures of these compounds were unambiguously determined by extensive NMR studies as well as by comparison with related compounds. Till now this is the second report of the occurrence of any unusual C-18 clerodane diterpenoid from nature. The crude light petroleum extract and the purified compound 3 demonstrated moderate free radical scavenging activity with IC50 values of 21.5 and 23.5 microg/mL, respectively.
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Bases de datos:
MEDLINE
Asunto principal:
Polyalthia
/
Diterpenos de Tipo Clerodano
Idioma:
En
Revista:
Nat Prod Commun
Año:
2010
Tipo del documento:
Article
País de afiliación:
Bangladesh