Developmental changes in action potential prolongation by K+-channel blockers in chick myocardium.
J Pharmacol Sci
; 115(2): 235-8, 2011.
Article
en En
| MEDLINE
| ID: mdl-21263207
ABSTRACT
The effects of K(+)-channel blockers on the action potential duration of the myocardium were examined in isolated right ventricles from the 7 - 10-day-old, 11 - 13-day-old, and 14 - 20-day-old embryo and 1 - 7-day-old hatched chicks. E-4031 significantly prolonged action potential duration at all developmental stages examined; the prolongation was largest in the 11 - 13-day-old embryo and was accompanied by early after-depolarizations. Chromanol 293B showed smaller prolongation at all stages examined. Terfenadine prolonged action potential duration in the 11 - 13-day-old embryo, but not in other stages. Thus, the chick ventricular myocardium changes its repolarization properties during development.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Potenciales de Acción
/
Canales de Potasio
/
Bloqueadores de los Canales de Potasio
/
Canales de Potasio de Tipo Rectificador Tardío
/
Ventrículos Cardíacos
/
Miocardio
Idioma:
En
Revista:
J Pharmacol Sci
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón