Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin.
Cancer Invest
; 29(3): 208-13, 2011 Mar.
Article
en En
| MEDLINE
| ID: mdl-21314329
ABSTRACT
Biological therapies can be beneficial in cancer patients. The present study aims to examine the inhibitory mechanism of curcumin on cancer cells in patients with colorectal cancer. The results showed that curcumin administration increased body weight, decreased serum TNF-alpha levels, increased apoptotic tumor cells, enhanced expression of p53 molecule in tumor tissue, and modulated tumor cell apoptotic pathway. We conclude that the curcumin treatment improves the general health of patients with colorectal cancer via the mechanism of increased p53 molecule expression in tumor cells and consequently speeds up tumor cell apoptosis.
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
/
Plantas_medicinales
Asunto principal:
Peso Corporal
/
Caquexia
/
Neoplasias Colorrectales
/
Proteína p53 Supresora de Tumor
/
Curcumina
/
Antineoplásicos
Tipo de estudio:
Clinical_trials
/
Etiology_studies
Idioma:
En
Revista:
Cancer Invest
Año:
2011
Tipo del documento:
Article
País de afiliación:
China