Olopatadine hydrochloride inhibits capsaicin-induced flare response in humans.
Pharmacology
; 87(3-4): 152-4, 2011.
Article
en En
| MEDLINE
| ID: mdl-21346393
ABSTRACT
Capsaicin, a vanilloid, has the potential for releasing substance P (SP) from sensory nerves. Topical application of capsaicin induces a flare response in the skin. However, it has not been clarified whether the release of SP is involved in the process of flare response or not. A potent antihistamine drug, olopatadine hydrochloride, is known to have inhibitory action against the release of SP. We examined the effects of olopatadine (at a dose of 5 mg) on skin reaction induced by topical application of capsaicin in 10 healthy subjects. The scores of capsaicin-induced flare responses after olopatadine administration were significantly lower at 30 min than at baseline. Our findings suggest that olopatadine hydrochloride could inhibit capsaicin-induced flare responses.
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Plantas_medicinales
Asunto principal:
Piel
/
Capsaicina
/
Antagonistas de los Receptores Histamínicos H1 no Sedantes
/
Dibenzoxepinas
/
Eritema
Idioma:
En
Revista:
Pharmacology
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón