Rosmarinic acid inhibits proliferation and induces apoptosis of hepatic stellate cells.
Biol Pharm Bull
; 34(3): 343-8, 2011.
Article
en En
| MEDLINE
| ID: mdl-21372382
ABSTRACT
Hepatic stellate cells (HSCs), activated during liver injury, are defined as the most important target in the therapy of hepatic fibrosis. In the present study, we evaluated the effect of Rosmarinic acid (RosA) on the proliferation and apoptosis in activated hepatic stellate cells (HSC-T6), which is useful to decrease this cell population. The proliferation of HSC-T6 was significantly inhibited after treated with various concentrations of RosA for different times. Flow cytometric analyses and transmission electron microscope (TEM) observations revealed that HSC-T6 treated with RosA underwent apoptosis in a time dependent manner and displayed typical apoptotic features in the cells. The phosphorylation in signal transducer and activator of transcription protein-3 (STAT3), which regulates cell survival, proliferation and differentiation in a variety of tissues, was markedly decreased as the result of Western blot assay and correlated with downregulation of CyclinD1 and B cell lymphoma/leukemia-2 (Bcl-2). In conclusion, these results suggested that RosA was able to inhibit proliferation and induce apoptosis in HSC-T6, partly due to the inhibition of phosphorylation in STAT3, which contributed to the reversal of hepatic fibrosis.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
Asunto principal:
Extractos Vegetales
/
Cinamatos
/
Apoptosis
/
Proliferación Celular
/
Depsidos
/
Células Estrelladas Hepáticas
/
Hígado
/
Cirrosis Hepática
Idioma:
En
Revista:
Biol Pharm Bull
Año:
2011
Tipo del documento:
Article
País de afiliación:
China