[Chemical constituents from Callicarpa nudiflora and their hemostatic activity].
Zhongguo Zhong Yao Za Zhi
; 35(24): 3297-301, 2010 Dec.
Article
en Zh
| MEDLINE
| ID: mdl-21438394
ABSTRACT
OBJECTIVE:
To study the hemostatic effect of chemical constituents from Callicarpa nudiflora.METHOD:
The chemical constituents were isolated and purified via silica gel and Sephadex LH-20 column chromatography. Their structures were determined on the basis of spectral analysis. prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and fibrinogen (FIB) of the constituents rabbit blood samples were tested with rabbit blood in vitro.RESULT:
Eleven compounds were isolated and identified as two diterpenens 7alpha-hydroxy sandaracopimaric acid (1), 16, 17-dihydroxy-3-oxophyllocladane (2). Two phenoic glycosides acteoside (3), samioside(4). Three triterpenes 2alpha, 3alpha, 24-trihydroxy-ursa-12-en-28-oic acid (5), 2alpha, 3alpha, 19alpha-trihydroxyursa-12-en-28-oic acid-28-0-beta-D-glucopyranosyl ester (6), and 2alpha, 3alpha, 19alpha, 23-tetrahydroxy-ursa-12-en-28-oic acid-28-0-beta-D-glucopyranosyl ester (7). Four flavones rhamnazin (8), 5-Hydroxy-3, 7, 4'-trimethoxy-flavone (9) , 5-Hydroxy-3, 7, 3', 4'-tetramethoxyflavone (10), and luteoloside (11). All Compounds cannot significantly shorten the PT (P < 0.01), compounds 3, 4, 7, 10 can remarkedly increase APTT (P < 0.01), compound 5 can prolong the T( P < 0.01) obviously, and compound 8 can significantly increase the contents of FIB (P < 0.01).CONCLUSION:
Compounds 2, 4 and 10 were isolated from this genus for the first time, and compounds 1, 3, 5, 6, 7 and 9 had been isolated from this plant for the first time. The hemostatic effect of C. nudiflora may be related to the activation of the intrinsic blood coagulation system.
Buscar en Google
Bases de datos:
MEDLINE
Asunto principal:
Compuestos Orgánicos
/
Callicarpa
/
Hemostasis
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2010
Tipo del documento:
Article
País de afiliación:
China