Syntheses of marchantins C, O and P as promising highly bioactive compounds.
Nat Prod Commun
; 6(3): 393-402, 2011 Mar.
Article
en En
| MEDLINE
| ID: mdl-21485281
ABSTRACT
Recently, remarkable microtubule inhibitor and anti-tumor activities of the bis(bibenzyl) marchantin C--isolated from liverworts like Marchantia polymorpha since 1983--were found. In this paper we describe the efficient total synthesis of this subtype of bis(bibenzylic) compounds with two biarylether connections. Two selectively methylated derivatives known as natural compounds marchantin O and P were synthesized for the first time by modification of the arene subunits and can now be considered as promising highly bioactive compounds.
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Bases de datos:
MEDLINE
Asunto principal:
Éteres Fenílicos
/
Bibencilos
/
Fármacos Anti-VIH
/
Marchantia
/
Antibacterianos
/
Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Nat Prod Commun
Año:
2011
Tipo del documento:
Article
País de afiliación:
Alemania