Modified ethoxyethyl cyanoacrylate for therapeutic embolization of arteriovenous malformation.
J Biomed Mater Res
; 24(1): 65-77, 1990 Jan.
Article
en En
| MEDLINE
| ID: mdl-2154499
ABSTRACT
Aiming at alleviating the problems of using 2-cyanoacrylates as a material for therapeutic embolization, this experiment made some physical modifications by mixing contrast media. It was found that the physicochemical properties of 2-cyanoacrylates can be altered by changing the concentration and the composition of the contrast media added. A 50 wt% cyanoacrylate-50 wt% contrast medium mixture has enough radiopacity for the practical requirement for embolization. A mixture of 50 wt% (ethoxyethyl cyanoacrylate-5 wt% lactide/epsilon-caprolactone copolymer), 25 wt% lipiodol and 25 wt% tetrafluorodibromoethane provides a viscosity of 13.8 cP, a bonding strength of 14.9 kg/cm2, a set time of 6 s, and a spreading in canine blood of 33 mm. It was concluded that the mixture is much more satisfactory than the conventional cyanoacrylates as an embolus material in vitro. The results obtained by in vivo experiments and clinical trials so far suggest that the mixture is very promising as a material for embolization.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Malformaciones Arteriovenosas
/
Cianoacrilatos
/
Embolización Terapéutica
Idioma:
En
Revista:
J Biomed Mater Res
Año:
1990
Tipo del documento:
Article
País de afiliación:
Japón