Nonablative fractional photothermolysis for facial actinic keratoses: 6-month follow-up with histologic evaluation.
J Am Acad Dermatol
; 65(2): 349-356, 2011 Aug.
Article
en En
| MEDLINE
| ID: mdl-21621294
ABSTRACT
BACKGROUND:
A number of epidermal and papillary dermal skin conditions can be treated safely and effectively with fractional photothermolysis (FP).OBJECTIVE:
We sought to evaluate the effectiveness of FP with a 1550-nm fractionated erbium-doped fiber laser for the treatment of facial actinic keratoses (AKs).METHODS:
Fourteen men, ages 59 to 79 years, underwent 5 laser treatments (2- to 4-week intervals) at an energy fluence of 20 to 70 mJ and treatment level of 11 (8-10 passes), corresponding to 32% to 40% surface area coverage. AK counts and photographs were taken at baseline, before each treatment, and at 1-, 3-, and 6-month follow-ups after the last treatment. Biopsies were performed at baseline and at the 3-month follow-up. The clinical improvement of the actinic lesions was evaluated by a dermatologist using digital photography and lesion counts at all 3 follow-up visits.RESULTS:
The AK count for each patient was reduced on average by 73.1% (67.5%-77.7%) at the 1-month, 66.2% (60.0%-71.5%) at the 3-month, and 55.6% (43.9%-64.8%) at the 6-month follow-up visit. Excluding two cases, all biopsy specimens (baseline and at the 3-month follow-up) were positive for histologic features of AK and/or squamous cell carcinoma.LIMITATIONS:
This study is limited by a small number of patients; therefore further clinical studies are warranted.CONCLUSIONS:
FP decreases the number of clinical AKs; however, posttreatment biopsy specimens indicate the histologic persistence of AKs (epidermal tumors). FP is not an adequate single-treatment modality for AKs.
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_energeticas
Asunto principal:
Terapia por Luz de Baja Intensidad
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Dermatosis Facial
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Láseres de Estado Sólido
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Queratosis Actínica
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
En
Revista:
J Am Acad Dermatol
Año:
2011
Tipo del documento:
Article