Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists.
Bioorg Med Chem Lett
; 21(14): 4343-8, 2011 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-21676612
ABSTRACT
We describe the discovery and optimization of a novel series of benzofuran EP(1) antagonists, leading to the identification of 26d, a novel nonacidic EP(1) antagonist which demonstrated efficacy in preclinical models of chronic inflammatory pain.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Benzofuranos
/
Antiinflamatorios no Esteroideos
/
Subtipo EP1 de Receptores de Prostaglandina E
Idioma:
En
Revista:
Bioorg Med Chem Lett
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido