Inhibition of HIV-1 reverse transcriptase associated activities by the hydroalcoholic extract of Casimiroa edulis seeds.
Nat Prod Res
; 25(11): 1067-73, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21726129
ABSTRACT
The hydroalcoholic extract obtained from the seeds of Casimiroa edulis cultivated in Sardinia (Italy) have been assayed on the two enzymatic-associated activities of the HIV-1 reverse transcriptase (RT), the RNA-dependent DNA polymerase (RDDP) and the ribonuclease H. In biochemical assays, the extract inhibited both activities in a dose-dependent manner, showing a 10-fold more potent inhibition of the HIV-1 RT RDDP activity. Furthermore, the extract was cytotoxic on K562 cell replication.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Semillas
/
Extractos Vegetales
/
Inhibidores de la Transcriptasa Inversa
/
Casimiroa
/
Transcriptasa Inversa del VIH
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Nat Prod Res
Año:
2011
Tipo del documento:
Article
País de afiliación:
Italia