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Inhibition of HIV-1 reverse transcriptase associated activities by the hydroalcoholic extract of Casimiroa edulis seeds.
Esposito, Francesca; Zinzula, Luca; Maxia, Andrea; Tramontano, Enzo; Sanna, Cinzia.
Afiliación
  • Esposito F; Department of Applied Sciences in Biosystems, University of Cagliari, Cagliari, Italy.
Nat Prod Res ; 25(11): 1067-73, 2011 Jul.
Article en En | MEDLINE | ID: mdl-21726129
ABSTRACT
The hydroalcoholic extract obtained from the seeds of Casimiroa edulis cultivated in Sardinia (Italy) have been assayed on the two enzymatic-associated activities of the HIV-1 reverse transcriptase (RT), the RNA-dependent DNA polymerase (RDDP) and the ribonuclease H. In biochemical assays, the extract inhibited both activities in a dose-dependent manner, showing a 10-fold more potent inhibition of the HIV-1 RT RDDP activity. Furthermore, the extract was cytotoxic on K562 cell replication.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Semillas / Extractos Vegetales / Inhibidores de la Transcriptasa Inversa / Casimiroa / Transcriptasa Inversa del VIH Tipo de estudio: Risk_factors_studies Idioma: En Revista: Nat Prod Res Año: 2011 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Semillas / Extractos Vegetales / Inhibidores de la Transcriptasa Inversa / Casimiroa / Transcriptasa Inversa del VIH Tipo de estudio: Risk_factors_studies Idioma: En Revista: Nat Prod Res Año: 2011 Tipo del documento: Article País de afiliación: Italia