[Central regulation of body temperature by RANKL/RANK pathway].
Clin Calcium
; 21(8): 1201-8, 2011 Aug.
Article
en Ja
| MEDLINE
| ID: mdl-21814026
ABSTRACT
Receptor-activator of NF-κB ligand (RANKL) and its specific receptor RANK are key regulators of bone remodeling, lymph node formation, establishment of the thymic microenviroment, mammary gland development during pregnancy, bone metastasis in cancer and sex-hormone, progestin, -driven breast cancer. RANKL and RANK are also expressed in the central nervous systems (CNS) especially existed in the main region of thermoregulation. Central RANKL injection to the rodents induces fever via PGE(2)/EP3R pathway. This pathway is related with inflammation related fever. On the other hand, female mice with RANK gene deletion in neuron and astrocytes show increased their basal body temperature at the dark phase, which suggests RANKL/RANK system also regulates physiological thremoregulation in female. Not only in rodents but also in human, two children with a homozygous RANK mutation exhibit an abrogated fever response in pneumonia compare with the age-matched children with pneumonia. Thus, the central RANKL/RANK pathway has an important role for thermoregulation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Temperatura Corporal
/
Regulación de la Temperatura Corporal
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Ligando RANK
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Receptor Activador del Factor Nuclear kappa-B
Idioma:
Ja
Revista:
Clin Calcium
Año:
2011
Tipo del documento:
Article