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Phytochemical investigation characterisation and anticonvulsant activity of Ricinus communis seeds in mice.
Tripathi, Avinash Chandra; Gupta, Rajiv; Saraf, Shailendra K.
Afiliación
  • Tripathi AC; Faculty of Pharmacy, Northern India Engineering College, Lucknow, UP, India.
Nat Prod Res ; 25(19): 1881-4, 2011 Nov.
Article en En | MEDLINE | ID: mdl-21870936
ABSTRACT
The ethanol extract of the dried, powdered hull portion of Ricinus communis seeds indicated the presence of alkaloids, steroids, flavonoids, glycosides and phenolics, amongst others. Ricinine was isolated as an active constituent and characterised by various chemical and spectroscopic techniques. The anticonvulsant activity of the isolated compound was evaluated in mice using the maximal electroshock (MES) model. The isolated compound at a dose of 60 mg kg⁻¹ body weight, orally, significantly (p < 0.05) reduced the extensor tonus phase of convulsion by MES-induced seizures in albino mice when compared with the standard drug diazepam (30 mg kg⁻¹ body weight, orally). The results of this study support the folkloric use of the plant in epileptic remedies.
Asunto(s)

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ricinus / Semillas / Extractos Vegetales / Anticonvulsivantes Idioma: En Revista: Nat Prod Res Año: 2011 Tipo del documento: Article País de afiliación: India

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ricinus / Semillas / Extractos Vegetales / Anticonvulsivantes Idioma: En Revista: Nat Prod Res Año: 2011 Tipo del documento: Article País de afiliación: India