Phytochemical investigation characterisation and anticonvulsant activity of Ricinus communis seeds in mice.
Nat Prod Res
; 25(19): 1881-4, 2011 Nov.
Article
en En
| MEDLINE
| ID: mdl-21870936
ABSTRACT
The ethanol extract of the dried, powdered hull portion of Ricinus communis seeds indicated the presence of alkaloids, steroids, flavonoids, glycosides and phenolics, amongst others. Ricinine was isolated as an active constituent and characterised by various chemical and spectroscopic techniques. The anticonvulsant activity of the isolated compound was evaluated in mice using the maximal electroshock (MES) model. The isolated compound at a dose of 60 mg kg⻹ body weight, orally, significantly (p < 0.05) reduced the extensor tonus phase of convulsion by MES-induced seizures in albino mice when compared with the standard drug diazepam (30 mg kg⻹ body weight, orally). The results of this study support the folkloric use of the plant in epileptic remedies.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ricinus
/
Semillas
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Extractos Vegetales
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Anticonvulsivantes
Idioma:
En
Revista:
Nat Prod Res
Año:
2011
Tipo del documento:
Article
País de afiliación:
India