Comparison of intravesical hyaluronic acid instillation and hyperbaric oxygen in the treatment of radiation-induced hemorrhagic cystitis.
BJU Int
; 109(5): 691-4, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-21895939
ABSTRACT
OBJECTIVE:
⢠To compare the efficacy of intravesical hyaluronic acid (HA) instillation and hyperbaric oxygen (HBO) in the treatment of radiation-induced haemorrhagic cystitis (HC). PATIENTS ANDMETHODS:
⢠In total 36 patients who underwent radiotherapy for their pelvic malignancies and subsequently suffered from HC were randomly divided into an HA group and an HBO group. ⢠Symptoms of haematuria, frequency of voiding and the visual analogue scale of pelvic pain (range 0-10) were evaluated before and after the treatment with follow-up of 18 months.RESULTS:
⢠All patients completed this study and no obvious side effects of intravesical HA were recorded. ⢠The improvement rate showed no statistical difference between the two groups at 6, 12 and 18 months after treatment. ⢠Decrease of frequency was significant in both groups 6 months after treatment, but was only significant in the HA group 12 months after therapy. ⢠The improvement in the visual analogue scale remained significant in both groups for 18 months.CONCLUSIONS:
⢠Intravesical instillation of HA was as effective in treating radiation-induced HC as HBO. ⢠It is well tolerated and resulted in a sustained decrease of bladder bleeding, pelvic pain and frequency of voiding for at least 12 months.
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Oxigenoterapia_hiperbrica
Asunto principal:
Traumatismos por Radiación
/
Cistitis
/
Hemorragia
/
Ácido Hialurónico
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Oxigenoterapia Hiperbárica
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
BJU Int
Año:
2012
Tipo del documento:
Article
País de afiliación:
China