Isolated neonatal seizures: when to suspect inborn errors of metabolism.
Pediatr Neurol
; 45(5): 283-91, 2011 Nov.
Article
en En
| MEDLINE
| ID: mdl-22000307
ABSTRACT
Neonatal seizures are common, and often comprise the first clinical indicator of central nervous system dysfunction. Although most neonatal seizures are secondary to processes such as hypoxic-ischemic injury, infection, or cortical malformations (which are readily identifiable through routine testing and imaging), seizures secondary to inborn errors of metabolism can be much more difficult to diagnose, and thus a high index of suspicion is required. The early diagnosis of inborn errors of metabolism is crucial, considering that many can receive effective treatment (e.g., dietary supplementation or restriction) with favorable long-term outcomes. This review emphasizes the importance of considering inborn errors of metabolism in the differential diagnosis of neonatal seizures, discusses red flags for inborn errors of metabolism as a cause of neonatal seizures, and provides an overview of diagnoses and treatments of inborn errors of metabolism most commonly associated with neonatal seizures.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Epilepsia Benigna Neonatal
/
Errores Innatos del Metabolismo
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Idioma:
En
Revista:
Pediatr Neurol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos