Echium oil reduces atherosclerosis in apoB100-only LDLrKO mice.
Atherosclerosis
; 220(1): 118-21, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22100249
ABSTRACT
INTRODUCTION:
The anti-atherogenic and hypotriglyceridemic properties of fish oil are attributed to its enrichment in eicosapentaenoic acid (EPA; 205, n-3) and docosahexaenoic acid (DHA; 226, n-3). Echium oil contains stearidonic acid (SDA; 184, n-3), which is metabolized to EPA in humans and mice, resulting in decreased plasma triglycerides.OBJECTIVE:
We used apoB100 only, LDLrKO mice to investigate whether echium oil reduces atherosclerosis.METHODS:
Mice were fed palm, echium, or fish oil-containing diets for 16 weeks and plasma lipids, lipoproteins, and atherosclerosis were measured.RESULTS:
Compared to palm oil, echium oil feeding resulted in significantly less plasma triglyceride and cholesterol levels, and atherosclerosis, comparable to that of fish oil.CONCLUSION:
This is the first report that echium oil is anti-atherogenic, suggesting that it may be a botanical alternative to fish oil for atheroprotection.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Aceites de Plantas
/
Receptores de LDL
/
Echium
/
Aterosclerosis
/
Apolipoproteína B-100
Idioma:
En
Revista:
Atherosclerosis
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos