[Effects of high dose glycosides of Tripterygium wilfordii Hook. f on the fertility of young rats].

OBJECTIVE: To explore the effects of high dose glycosides of Tripterygium wilfordii Hook. f (GTW) on the fertility of young rats. METHODS: Fifty female SD young rats and 50 male SD young rats were randomly divided into the blank group and the GTW group, 25 in each. GTW was given at the daily dose of 9 mg/kg. After 12 weeks of medication, the male rats were caged together with healthy adult female rats in the ratio of 1:1. The female rats were caged together with healthy adult male rats in the ratio of 2:1. The cage process lasted for two weeks, totally for three times. The pregnant rate of female rats and the survival rate of baby rats were then observed. RESULTS: There was no significant difference in the pregnant rate or the survival rate of baby rats in the GTW group. CONCLUSION: High dose GTW showed no obvious effects on the fertility of adult rats or the growth and development of new born rats.