Suffruyabiosides A and B, two new monoterpene diglycosides from moutan cortex.
Molecules
; 17(5): 4915-23, 2012 Apr 30.
Article
en En
| MEDLINE
| ID: mdl-22547314
ABSTRACT
Two new monoterpene diglycosides, suffruyabiosides A and B, and seven known compounds 3-9 were isolated from Moutan Cortex (root cortex of Paeonia suffruticosa Andrews). The structures were elucidated on the basis of 2D NMR spectral data. Suffruyabiosides A and B are rare monoterpene diglycosides, including a cellobiose in the molecules. Salicylpaeoniflorin (4) had a antiproliferation effect similar to paeoniflorin (3) on human lung adenocarcinoma epitherial A549 cells. Galloylpaeoniflorin (8) and salicylpaeoniflorin (4) revealed a more pronounced radical scavenging effect than a-tocopherol (positive control). An increase in the number of phenolic hydroxyl groups produced a more effective radical scavenging effect [8 > mudanpioside E (6) > oxypaeoniflorin (5)]. Comparison of the effects of 4 and 5 showed that o-substitution with a phenolic hydroxyl group was more effective than p-substitution. The results suggest that salicylpaeoniflorin (4) may be useful as a cytotoxic and a radical scavenging agent.
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
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Medicina_china
Asunto principal:
Medicamentos Herbarios Chinos
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Extractos Vegetales
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Depuradores de Radicales Libres
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Paeonia
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Monoterpenos
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Glucósidos
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Glicósidos
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Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Molecules
Año:
2012
Tipo del documento:
Article
País de afiliación:
Japón