Effects of valproic acid and magnesium sulphate on rocuronium requirement in patients undergoing craniotomy for cerebrovascular surgery.
Br J Anaesth
; 109(3): 407-12, 2012 Sep.
Article
en En
| MEDLINE
| ID: mdl-22767646
ABSTRACT
BACKGROUND:
Many anti-epileptics cause resistance to non-depolarizing neuromuscular blocking agents, but this has not been reported for valproic acid (VPA). We hypothesized that VPA would increase the rocuronium requirement and that magnesium sulphate (MgSO(4)) may reduce this increase.METHODS:
Fifty-five patients undergoing cerebrovascular surgeries were studied. Subjects were allocated into three groups at a 111 ratio Groups VM, VC, and C. Groups VM and VC were given VPA premedication; Group C was not. A rocuronium injection (0.6 mg kg(-1) i.v.) was administered to Group VM, followed by MgSO(4) as a 50 mg kg(-1) i.v. bolus and 15 mg kg(-1) h(-1) infusion. The same volume of 0.9% saline was administered to the other groups. Supplementary rocuronium (0.15 mg kg(-1)) was given whenever the train-of-four count reached 2. Rocuronium requirements (primary outcome), mean arterial pressure (MAP), heart rate (HR), nausea, vomiting, shivering, and use of anti-emetics and nicardipine were compared.RESULTS:
Group VC showed the highest rocuronium requirement [mg kg(-1) h(-1) 0.47 (0.08) vs 0.33 (0.12) (Group C), 0.31 (0.07) (Group VM); P<0.001]. MAP, intraoperative HR, nausea, vomiting, shivering, and use of anti-emetics and nicardipine were not significantly different among the groups. Postoperative HR was lower in Group VM than in Group VC.CONCLUSIONS:
VPA increased the rocuronium requirement, and MgSO(4) infusion attenuated this increase.
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Trastornos Cerebrovasculares
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Ácido Valproico
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Fármacos Neuromusculares no Despolarizantes
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Androstanoles
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Sulfato de Magnesio
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Anticonvulsivantes
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
Br J Anaesth
Año:
2012
Tipo del documento:
Article