[Apoptosis of the hypothalamus neurosecretory cells in stress and ageing: the role of immune modulators].
Ross Fiziol Zh Im I M Sechenova
; 98(4): 542-50, 2012 Apr.
Article
en Ru
| MEDLINE
| ID: mdl-22834344
ABSTRACT
There is assumption about active role of immune modulators in cell death process. The involvement of interferon-alpha and cycloferon in apoptosis regulation of hypothalamic neurons of mice during stress and aging was studied. We determined the expression of apoptosis markers (Bcl-2, Mcl-1, Bax) in comparison with apoptosis level. We have found that immune modulators suppress activity of nonapeptidergic neurons. Thus, interferon-alpha treatment reduces synthesis of Bcl-2; cycloferon treatment inhibits expression of Bax and Bcl-2. So the role of immune modulators in neuron apoptosis depends on the stage of ontogenesis and type of immune modulator. Cycloferon is able to reduce the level of age-dependent apoptosis of neurons in aging, but under stress condition both interferon-alpha and cycloferon act as protectors of cell death.
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Bases de datos:
MEDLINE
Asunto principal:
Acridinas
/
Envejecimiento
/
Interferón-alfa
/
Hiperoxia
/
Hipotálamo
/
Neuronas
Idioma:
Ru
Revista:
Ross Fiziol Zh Im I M Sechenova
Año:
2012
Tipo del documento:
Article