Neural tube defects and maternal intake of micronutrients related to one-carbon metabolism or antioxidant activity.
Birth Defects Res A Clin Mol Teratol
; 94(11): 864-74, 2012 Nov.
Article
en En
| MEDLINE
| ID: mdl-22933447
ABSTRACT
BACKGROUND:
Maternal nutritional status has been evaluated to clarify its role in development of neural tube defects (NTDs). Maternal folate intake during pregnancy has been closely evaluated for its association with NTDs. The study objective was to examine associations between NTDs and other dietary periconceptional micronutrient intake, particularly nutrients involved in one-carbon metabolism or antioxidant activity.METHODS:
Using data from the National Birth Defects Prevention Study, 1997-2005, logistic regression models were used to estimate the relative risk of NTDs based on maternal micronutrient intake.RESULTS:
Results were stratified according to folic acid supplement use, race/ethnicity, and maternal body mass index. Analyses included 954 cases (300 with anencephaly, 654 with spina bifida) and 6268 controls. Higher intakes of folate, thiamin, betaine, iron, and vitamin A were associated with decreased risk of anencephaly among some ethnic and clinical groups. In some groups, higher intakes of thiamin, riboflavin, vitamin B(6) , vitamin C, vitamin E, niacin, and retinol were associated with decreased risk of spina bifida.CONCLUSION:
In addition to folic acid, other micronutrients, including thiamin, betaine, riboflavin, vitamin B(6) , vitamin C, vitamin E, niacin, iron, retinol, and vitamin A, may decrease the risk of NTD occurrence. Birth Defects Research (Part A) 2012. © 2012 Wiley Periodicals, Inc.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vitaminas
/
Carbono
/
Micronutrientes
/
Ácido Fólico
/
Defectos del Tubo Neural
/
Antioxidantes
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Birth Defects Res A Clin Mol Teratol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos