[Effect and mechanism of Danhong injection on isolated mesenteric arterial rings in rats].
Zhongguo Zhong Yao Za Zhi
; 37(17): 2607-11, 2012 Sep.
Article
en Zh
| MEDLINE
| ID: mdl-23236761
ABSTRACT
OBJECTIVE:
To study the effect and mechanism of Danhong injection on isolated mesenteric arterial rings in rats.METHOD:
An isolated vascular ring experiment was conducted to determine the changes in tension of vascular rings with a biological signal collection and analytical system.RESULT:
Danhong injection had no impact on the tension of vascular rings. Danhong injection showed a significant vasodilatation effect on treated arteria rings of norepinephrine, and no remarkable impact was made on the effect without endothium. It showed notable effect on blood vessels treated with Ca(2+) and no significant impact on those treated with caffeine. It could inhibit NE-induced intracellular calcium from releasing and external calcium from inflowing. No effects of potassium channel blockers on aorta ring tensile force were found.CONCLUSION:
Danhong injection shows significant vasodilation effect, which mainly works through vascular smooth muscle. Its vasodilation effect may be related to inhibitory receptor, voltage-dependent Ca(2+)-release and IP3 receptor-mediated Ca(2 +)-influx.
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Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Asunto principal:
Medicamentos Herbarios Chinos
/
Arterias Mesentéricas
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Año:
2012
Tipo del documento:
Article
País de afiliación:
China