[Effects of inhibitory activity on mycelial growth of Candida albicans and therapy for murine oral candidiasis by the combined use of terpinen-4-ol and a middle-chain fatty acid, capric acid].
Yakugaku Zasshi
; 133(1): 133-40, 2013.
Article
en Ja
| MEDLINE
| ID: mdl-23292030
ABSTRACT
The combined effect of terpinen-4-ol, the main component of tea tree oil, and capric acid against mycelial growth of Candida albicans and murine oral candidiasis was evaluated in vitro and in vivo. Mycelial growth of C. albicans was estimated by the Cristal violet method. Combination of these compounds revealed a potent synergistic inhibition of growth. Therapeutic efficacy of the combination was evaluated microbiologically in murine oral candidiasis, and its application of the compounds clearly demonstrated therapeutic activity. Based on these results, the combined agent of terpinen-4-ol and capric acid was discussed as a possible candidate for oral candidiasis therapy.
Buscar en Google
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
/
Plantas_medicinales
Asunto principal:
Terpenos
/
Candida albicans
/
Candidiasis Bucal
/
Ácidos Decanoicos
/
Antifúngicos
Idioma:
Ja
Revista:
Yakugaku Zasshi
Año:
2013
Tipo del documento:
Article
País de afiliación:
Japón