Timing of antioxidant supplementation is critical in improving anorexia in an experimental model of cancer.
Int J Food Sci Nutr
; 64(5): 570-4, 2013 Aug.
Article
en En
| MEDLINE
| ID: mdl-23301688
ABSTRACT
Increased oxidative stress may contribute to cancer anorexia, which could be ameliorated by antioxidant supplementation. methylcholanthrene (MCA) sarcoma-bearing Fisher rats were studied. After tumour inoculation, rats were randomly assigned to standard diet (CTR group, n = 6), or to an antioxidant-enriched diet (AOX group, n = 8). Eight more rats (STD-AOX group) switched from standard to antioxidant diet when anorexia developed. At the end of the study, food intake (FI, g/d), body weight and tumour weight (g) were recorded, and plasma samples were obtained. On day 16, anorexia has appeared only in CTR and STD-AOX animals. At the end of the study, FI in AOX animals was still higher than in the other groups (p = 0.08). No differences in body and tumour weights were observed among groups. However, hydrogen peroxide and interleukin-1ß levels were significantly reduced only in AOX rats. Data obtained suggest that early antioxidant supplementation improves cancer anorexia, ameliorates oxidative stress and reduces inflammation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sarcoma
/
Ingestión de Energía
/
Anorexia
/
Estrés Oxidativo
/
Suplementos Dietéticos
/
Antioxidantes
Tipo de estudio:
Etiology_studies
Idioma:
En
Revista:
Int J Food Sci Nutr
Año:
2013
Tipo del documento:
Article
País de afiliación:
Italia