Flavonoids from Astragalus membranaceus and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells.
Arch Pharm Res
; 37(2): 186-92, 2014 Feb.
Article
en En
| MEDLINE
| ID: mdl-23771500
ABSTRACT
Radix Astragali (Astragalus membranaceus) is an important traditional Chinese medicine that is widely used as a tonic to enhance the body's natural defense mechanisms. In this phytochemical study, 12 flavonoids, isoliquiritigenin (1), liquiritigenin (2), calycosin (3), calycosin 7-O-ß-D-glucoside (4), formononetin (5), formononetin 7-O-ß-D-glucoside (6), daidzein (7), daidzein 7-O-ß-D-glucoside (8), methylnissolin (9), methylnissolin 3-O-ß-D-glucoside (10), isomucronulatol (11), and isomucronulatol 7-O-ß-D-glucoside (12), were isolated from the roots of A. membranaceus. Their structures were elucidated by comparing spectroscopic data with reported values. The effects of the isolated compounds on lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells were investigated. Compounds 1 and 2 exhibited significant inhibitory effects on LPS-induced IL-6 and IL-12 p40 production, with IC50 values ranging from 2.7 to 6.1 µM. Compound 1 also showed a moderate inhibitory effect on LPS-stimulated production of TNF-α with an IC50 value of 20.1 µM. Further studies of the potential anti-inflammatory effects and benefits of flavonoids from A. membranaceus are warranted.
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Asunto principal:
Flavonoides
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Células Dendríticas
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Medicamentos Herbarios Chinos
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Lipopolisacáridos
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Citocinas
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Planta del Astrágalo
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Antiinflamatorios
Idioma:
En
Revista:
Arch Pharm Res
Año:
2014
Tipo del documento:
Article