A chrysin derivative suppresses skin cancer growth by inhibiting cyclin-dependent kinases.

Liu, Haidan; Liu, Kangdong; Huang, Zunnan; Park, Chan-Mi; Thimmegowda, N R; Jang, Jae-Hyuk; Ryoo, In-Ja; He, Long; Kim, Sun-Ok; Oi, Naomi; Lee, Ki Won; Soung, Nak-Kyun; Bode, Ann M; Yang, Yifeng; Zhou, Xinmin; Erikson, Raymond L; Ahn, Jong-Seog; Hwang, Joonsung; Kim, Kyoon Eon; Dong, Zigang; Kim, Bo-Yeon

Liu, Haidan; Liu, Kangdong; Huang, Zunnan; Park, Chan-Mi; Thimmegowda, N R; Jang, Jae-Hyuk; Ryoo, In-Ja; He, Long; Kim, Sun-Ok; Oi, Naomi; Lee, Ki Won; Soung, Nak-Kyun; Bode, Ann M; Yang, Yifeng; Zhou, Xinmin; Erikson, Raymond L; Ahn, Jong-Seog; Hwang, Joonsung; Kim, Kyoon Eon; Dong, Zigang; Kim, Bo-Yeon.

Afiliación

Liu H; From the World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363-883, Republic of Korea,; the Hormel Institute, University of Minnesota, Austin, Minnesota 55912,; the Department of Cardiothoracic Surgery and; Clinical Center for Gene Diagnosis and Thera
Liu K; From the World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363-883, Republic of Korea,; the Hormel Institute, University of Minnesota, Austin, Minnesota 55912,; the Basic Medical College, Zhengzhou University, ZhengZhou 450001 China, and.
Huang Z; the Hormel Institute, University of Minnesota, Austin, Minnesota 55912.
Park CM; From the World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363-883, Republic of Korea.
Thimmegowda NR; From the World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363-883, Republic of Korea.
Jang JH; the Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yangcheng-ri, Ochang, Cheongwon, Chungcheongbuk-do 363-883, Republic of Korea.
Ryoo IJ; the Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yangcheng-ri, Ochang, Cheongwon, Chungcheongbuk-do 363-883, Republic of Korea.
He L; From the World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363-883, Republic of Korea.
Kim SO; From the World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363-883, Republic of Korea.
Oi N; the Hormel Institute, University of Minnesota, Austin, Minnesota 55912.
Lee KW; the Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea.
Soung NK; From the World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363-883, Republic of Korea.
Bode AM; the Hormel Institute, University of Minnesota, Austin, Minnesota 55912.
Yang Y; the Department of Cardiothoracic Surgery and.
Zhou X; the Department of Cardiothoracic Surgery and.
Erikson RL; the Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Ahn JS; the Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Yangcheng-ri, Ochang, Cheongwon, Chungcheongbuk-do 363-883, Republic of Korea.
Hwang J; From the World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363-883, Republic of Korea.
Kim KE; the Department of Biochemistry, College of Natural Science, Chung Nam National University, Yuseong, Daejeon 305-764, Republic of Korea.
Dong Z; the Hormel Institute, University of Minnesota, Austin, Minnesota 55912,. Electronic address: zgdong@hi.umn.edu.
Kim BY; From the World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 363-883, Republic of Korea,. Electronic address: zgdong@hi.umn.edu.

J Biol Chem ; 288(36): 25924-25937, 2013 Sep 06.

Article en En | MEDLINE | ID: mdl-23888052

Asunto(s)

Carcinoma de Células Escamosas/tratamiento farmacológico; Quinasas Ciclina-Dependientes/antagonistas & inhibidores; Flavonoides/farmacología; Inhibidores de Proteínas Quinasas/farmacología; Neoplasias Cutáneas/tratamiento farmacológico; Regulación Alostérica/efectos de los fármacos; Animales; Sitios de Unión; Carcinoma de Células Escamosas/enzimología; Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/patología; Línea Celular Tumoral; Cristalografía por Rayos X; Quinasas Ciclina-Dependientes/genética; Quinasas Ciclina-Dependientes/metabolismo; Factor de Crecimiento Epidérmico/genética; Factor de Crecimiento Epidérmico/metabolismo; Flavonoides/química; Fase G1/efectos de los fármacos; Fase G1/genética; Humanos; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Modelos Moleculares; Trasplante de Neoplasias; Inhibidores de Proteínas Quinasas/química; Proteína de Retinoblastoma/genética; Proteína de Retinoblastoma/metabolismo; Fase S/efectos de los fármacos; Fase S/genética; Neoplasias Cutáneas/enzimología; Neoplasias Cutáneas/genética; Neoplasias Cutáneas/patología

Palabras clave

ATP; ATP-noncompetitive; CDK (Cyclin-dependent Kinase); CDK Inhibitor; Cell Cycle; Chemoprevention; Chrysin Derivative; Epidermal Growth Factor (EGF); Natural Compound

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Texto completo: 1 Asunto principal: Neoplasias Cutáneas / Flavonoides / Carcinoma de Células Escamosas / Quinasas Ciclina-Dependientes / Inhibidores de Proteínas Quinasas Tipo de estudio: Prognostic_studies Idioma: En Revista: J Biol Chem Año: 2013 Tipo del documento: Article

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