Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.
ACS Chem Neurosci
; 4(11): 1479-87, 2013 Nov 20.
Article
en En
| MEDLINE
| ID: mdl-23937066
ABSTRACT
Danshen or Chinese red sage (Salvia miltiorrhiza, Bunge) is used by traditional Chinese medicine (TCM) practitioners to treat neurological, cardiovascular, and cerebrovascular disorders and is included in some TCM formulations to control epileptic seizures. In this study, acetonic crude extracts of danshen inhibited pentylenetetrazol (PTZ)-induced seizure activity in zebrafish larvae. Subsequent zebrafish bioassay-guided fractionation of the extract resulted in the isolation of four major tanshinones, which suppressed PTZ-induced activity to varying degrees. One of the active tanshinones, tanshinone IIA, also reduced c-fos expression in the brains of PTZ-exposed zebrafish larvae. In rodent seizure models, tanshinone IIA showed anticonvulsive activity in the mouse 6-Hz psychomotor seizure test in a biphasic manner and modified seizure thresholds in a complex manner for the mouse i.v. PTZ seizure assay. Interestingly, tanshinone IIA is used as a prescription drug in China to address cerebral ischemia in patients. Here, we provide the first in vivo evidence demonstrating that tanshinone IIA has anticonvulsant properties as well.
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
/
Aromoterapia
/
Plantas_medicinales
Asunto principal:
Pentilenotetrazol
/
Convulsiones
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Medicamentos Herbarios Chinos
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Abietanos
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Medicina Tradicional China
/
Anticonvulsivantes
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
ACS Chem Neurosci
Año:
2013
Tipo del documento:
Article
País de afiliación:
Bélgica