Multivitamin supplementation improves haematologic status in children born to HIV-positive women in Tanzania.
J Int AIDS Soc
; 16: 18022, 2013 Aug 13.
Article
en En
| MEDLINE
| ID: mdl-23948440
ABSTRACT
INTRODUCTION:
Anaemia is prevalent among children born to HIV-positive women, and it is associated with adverse effects on cognitive and motor development, growth, and increased risks of morbidity and mortality.OBJECTIVE:
To examine the effect of daily multivitamin supplementation on haematologic status and mother-to-child transmission (MTCT) of HIV through breastfeeding.METHODS:
A total of 2387 infants born to HIV-positive women from Dar es Salaam, Tanzania were enrolled in a randomized, double-blind, placebo-controlled trial, and provided a daily oral supplement of multivitamins (vitamin B complex, C and E) or placebo at age 6 weeks for 24 months. Among them, 2008 infants provided blood samples and had haemoglobin concentrations measured at baseline and during a follow-up period. Anaemia was defined as haemoglobin concentrations <11 g/dL and severe anaemia <8.5 g/dL.RESULTS:
Haemoglobin concentrations among children in the treatment group were significantly higher than those in the placebo group at 12 (9.77 vs. 9.64 g/dL, p=0.03), 18 (9.76 vs. 9.57 g/dL, p=0.004), and 24 months (9.93 vs. 9.75 g/dL, p=0.02) of follow-up. Compared to those in the placebo group, children in the treatment group had a 12% lower risk of anaemia (hazard ratio (HR) 0.88; 95% CI 0.79-0.99; p=0.03). The treatment was associated with a 28% reduced risk of severe anaemia among children born to women without anaemia (HR 0.72; 95% CI 0.56-0.92; p=0.008), but not among those born to women with anaemia (HR 1.10; 95% CI 0.79-1.54; p=0.57; p for interaction=0.007). One thousand seven hundred fifty three infants who tested HIV-negative at baseline and had HIV testing during follow-up were included in the analysis for MTCT of HIV. No association was found between multivitamin supplements and MTCT of HIV.CONCLUSIONS:
Multivitamin supplements improve haematologic status among children born to HIV-positive women. Further trials focusing on anaemia among HIV-exposed children are warranted in the context of antiretroviral therapy.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vitaminas
/
Infecciones por VIH
/
Transmisión Vertical de Enfermedad Infecciosa
/
Dieta
/
Anemia
Tipo de estudio:
Clinical_trials
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Int AIDS Soc
Año:
2013
Tipo del documento:
Article
País de afiliación:
Estados Unidos