Anti-allergic flavones from Arthraxon hispidus.
Chem Pharm Bull (Tokyo)
; 61(9): 920-6, 2013.
Article
en En
| MEDLINE
| ID: mdl-23995356
ABSTRACT
Bioactivity-guided fractionation for an EtOAc-soluble fraction of methanolic extract of Arthraxon hispidus, using primary cell assay with bone marrow-derived mast cells (BMMC), led to an isolation of six new flavones and nine known compounds. The structures of the new compounds were established by one dimensional (1D)- and 2D-NMR spectroscopic data, as luteolin 8-C-ß-kerriopyranoside (1), luteolin 8-acetic acid methyl ester (2), 7-methyl-luteolin 8-C-ß-(6-deoxyxylo-3-uloside) (3), apigenin 8-C-α-fucopyranoside (4), apigenin 8-C-ß-fucopyranoside (5) and luteolin 8-C-ß-fucopyranoside (6). All the isolates were evaluated for inhibitory activities on interleukin-6 release in the primary cultures using BMMC. Of the tested compounds, compounds 2, 3 and 10 were found to inhibit interleukin-6 release. Furthermore, compound 2 displayed inhibitory activity against prostaglandin D2, leukotriene C4, and ß-hexosaminidase releases.
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Bases de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Antialérgicos
/
Flavonas
/
Poaceae
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Año:
2013
Tipo del documento:
Article