Homoarginine levels are regulated by L-arginine:glycine amidinotransferase and affect stroke outcome: results from human and murine studies.

Choe, Chi-un; Atzler, Dorothee; Wild, Philipp S; Carter, Angela M; Böger, Rainer H; Ojeda, Francisco; Simova, Olga; Stockebrand, Malte; Lackner, Karl; Nabuurs, Christine; Marescau, Bart; Streichert, Thomas; Müller, Christian; Lüneburg, Nicole; De Deyn, Peter P; Benndorf, Ralf A; Baldus, Stephan; Gerloff, Christian; Blankenberg, Stefan; Heerschap, Arend; Grant, Peter J; Magnus, Tim; Zeller, Tanja; Isbrandt, Dirk; Schwedhelm, Edzard

Choe, Chi-un; Atzler, Dorothee; Wild, Philipp S; Carter, Angela M; Böger, Rainer H; Ojeda, Francisco; Simova, Olga; Stockebrand, Malte; Lackner, Karl; Nabuurs, Christine; Marescau, Bart; Streichert, Thomas; Müller, Christian; Lüneburg, Nicole; De Deyn, Peter P; Benndorf, Ralf A; Baldus, Stephan; Gerloff, Christian; Blankenberg, Stefan; Heerschap, Arend; Grant, Peter J; Magnus, Tim; Zeller, Tanja; Isbrandt, Dirk; Schwedhelm, Edzard.

Afiliación

Choe CU; Departments of Neurology (C.C., O.S., C.G., T.M.), Experimental Neuropediatrics (C.C., M.S., D.I.), Department of Clinical Pharmacology and Toxicology (D.A., R.H.B., N.L., R.A.B., E.S.), and German Center for Cardiovascular Research (D.A., P.S.W., R.H.B., S.B., T.Z., E.S.), Clinic for General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany (F.O., C.M., S. Baldus, S. Blankenberg, T.Z.); Department of Clinical Chemistry, University Medical Center Hamburg-Eppendorf,

Circulation ; 128(13): 1451-61, 2013 Sep 24.

Article en En | MEDLINE | ID: mdl-24004504

Asunto(s)

Amidinotransferasas/genética; Arginina/genética; Homoarginina/genética; Accidente Cerebrovascular/genética; Adulto; Anciano; Animales; Estudios de Cohortes; Modelos Animales de Enfermedad; Femenino; Estudio de Asociación del Genoma Completo; Células HEK293; Humanos; Masculino; Ratones; Ratones Endogámicos C57BL; Persona de Mediana Edad; Polimorfismo de Nucleótido Simple/genética; Estudios Prospectivos; Accidente Cerebrovascular/diagnóstico; Resultado del Tratamiento

Palabras clave

L-arginine:glycine amidinotransferase; genome-wide association studies; homoarginine; single nucleotide polymorphism; stroke

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Arginina / Accidente Cerebrovascular / Amidinotransferasas / Homoarginina Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Circulation Año: 2013 Tipo del documento: Article

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