[Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism].

ABSTRACT

OBJECTIVE: To observe the effect of psoralidine in rats with ovariectomy, and preliminarily study its mechanism. METHOD: Sixty female Sprague-Dawley rats were divided into 5 groups the sham operation group, the model group, the psoralidine low-dose group (4 mg x kg(-1)), the psoralidine high-dose group (16 mg x kg(-1)) and the Zhuangguzhitong capsule group, with 12 rats in each group. Thirteen weeks later, their blood and bone samples were collected to detect bone density, bone biochemistry, pathomorphology, serum E2 and CT. RESULT: Psoralidine could up-regulate the bone density of lumbar vertebra and thighbone of rats with ovariectomy (P < 0.05), the maximum bending strength of thighbone (P < 0.05), and serum E2 and CT (P < 0.05). CONCLUSION: Psoralidine has a good active effect on postmenopausal antiosteoporosis. Its mechanism may be related to such pathways as E2 and CT.