Inhibition of cysteine proteinases by a protein inhibitor from potato.
FEBS Lett
; 269(2): 328-30, 1990 Sep 03.
Article
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| MEDLINE
| ID: mdl-2401357
ABSTRACT
The inhibitory specificity of a protein from potato tubers that inhibits cysteine proteinases (potato cysteine proteinase inhibitor, PCPI) has been compared with that of chicken egg-white cystatin. Most proteinases that are inhibited by cystatin were also inhibited by PCPI, but the potato inhibitor inhibited stem bromelain and fruit bromelain, which are not inhibited by cystatin, and for which no protein inhibitor of comparable potency has previously been described. In contrast, papaya proteinase IV was unaffected by PCPI as it is by the cystatins, and the exopeptidase, dipeptidyl peptidase I, is inhibited by cystatins, but was unaffected by PCPI. The differences in inhibitory specificity between these proteins may well reflect differences between superfamilies of cysteine proteinase inhibitors.
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Bases de datos:
MEDLINE
Asunto principal:
Cisteína Endopeptidasas
/
Inhibidores de Cisteína Proteinasa
Idioma:
En
Revista:
FEBS Lett
Año:
1990
Tipo del documento:
Article
País de afiliación:
Reino Unido