Microvascular disorders in obese Zucker rats are restored by a rice bran diet.
Nutr Metab Cardiovasc Dis
; 24(5): 524-31, 2014 May.
Article
en En
| MEDLINE
| ID: mdl-24361072
ABSTRACT
BACKGROUND AND AIM:
Nutritional-based approaches aimed to prevent microvascular dysfunction associated to obesity present potential advantages over pharmacological strategies. Our aim was to test whether a rice bran enzymatic extract (RBEE)-supplemented diet could attenuate microvascular alterations in obese rats. METHODS ANDRESULTS:
Lean and obese Zucker rats were fed standard diet supplemented or not with 1% and 5% RBEE for 20 weeks. Functional studies were performed in small mesenteric arteries in isometric myograph. Immunoblotting and fluorescence studies were made in arterial homogenates and arterial sections, respectively. RBEE-supplementation restored microvascular function in obese rats through a marked increase in NO and endothelial-derived hyperpolarizing factor contribution by up-regulation of eNOS and calcium-activated potassium channels expression, respectively, in association to a substantial reduction of microvascular inflammation and superoxide anion formation. These data agrees with the beneficial actions of RBEE on dyslipidemia, hyperinsulinemia and hypertension in obesity.CONCLUSION:
The multi-factorial properties of RBEE-diet, especially for restoring the function of small resistance arteries shows this dietary-based approach to be a promising candidate for prevention of microvascular alterations in obesity, which are crucial in cardiovascular events in obese subjects.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Oryza
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Fibras de la Dieta
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Hipertensión
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Obesidad
Idioma:
En
Revista:
Nutr Metab Cardiovasc Dis
Año:
2014
Tipo del documento:
Article
País de afiliación:
España