8-hydroxycudraxanthone G suppresses IL-8 production in SP-C1 tongue cancer cells.
Nat Prod Commun
; 9(1): 75-8, 2014 Jan.
Article
en En
| MEDLINE
| ID: mdl-24660467
ABSTRACT
Production of IL-8 primarily promotes angiogenic responses in cancer cells, which lead to favorable disease progression. Suppressing this production may, therefore, be a significant therapeutic intervention in targeting tumor angiogenesis. This study aimed to evaluate the reduction effects of xanthones in cancer cell lines. Nine known prenylated xanthones (1-9), isolated from the pericarp of Garcinia mangostana Linn (GML), were tested for their ability to suppress IL-8 (interleukin-8) of the SP-C1 (Supri's Clone 1) tongue cancer cell line. Of these compounds, 8-hydroxycudraxanthone-G (4) suppressed IL-8 within 48 hours. This is the first report of 8-hydroxycudraxanthone G suppressing the production of IL-8 (45% at 15.7 microg/mL in 48 hours). These results suggest that the prolonged suppression of IL-8 production by cancer cell lines is concerned in the anti-cancer activity of 8-hydroxycudraxanthone.
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Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Terapias_biologicas
Asunto principal:
Interleucina-8
/
Garcinia mangostana
/
Xantonas
/
Antineoplásicos Fitogénicos
Idioma:
En
Revista:
Nat Prod Commun
Año:
2014
Tipo del documento:
Article