Leishmanicidal evaluation of tetrahydroprotoberberine and spirocyclic erythrina-alkaloids.
Molecules
; 19(5): 5692-703, 2014 May 05.
Article
en En
| MEDLINE
| ID: mdl-24802983
ABSTRACT
Leishmaniasis is one of the World's most problematic diseases in developing countries. Traditional medicines to treat leishmaniasis have serious side effects, as well as significant parasite resistance problems. In this work, two alkaloids 1 and 2 were obtained from Corydalis govaniana Wall and seven alkaloids 3-9, were obtained from Erythrina verna. The structures of the compounds were confirmed by mass spectrometry and 1D- and 2D-NMR spectroscopy. The leishmanicidal activity of compounds 1-9 against Leishmania amazonensis was tested on promastigote forms and cytotoxicity against J774 (macrophage cell line) was assessed in vitro. Compound 1 showed potent activity (IC50 = 0.18 µg/mL), compared with the standard amphotericin B (IC50 = 0.20 µg/mL). The spirocyclic erythrina-alkaloids showed lower leishmanicidal activity than dibenzoquinolizine type alkaloids.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Alcaloides de Berberina
/
Leishmaniasis
/
Erythrina
/
Leishmania
Tipo de estudio:
Evaluation_studies
Idioma:
En
Revista:
Molecules
Año:
2014
Tipo del documento:
Article
País de afiliación:
Brasil