Dammarane-type triterpenoids from Gentianella azurea.
J Nat Prod
; 77(5): 1201-9, 2014 May 23.
Article
en En
| MEDLINE
| ID: mdl-24806310
ABSTRACT
Thirteen new dammarane-type triterpenoids (1-13) and four known analogues, gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17), were isolated from Gentianella azurea. Their structures were elucidated by detailed analysis of the NMR, MS, and X-ray crystallographic data. This is the first report of dammarane-type triterpenoids in the Gentianella genus. In addition, the known structures of gentirigenic acid (14) and the gentirigeosides A, B, and E (15-17) were revised based on the X-ray diffraction analysis. Gentirigeoside A (15) was found to inhibit nitric oxide production in RAW 264.7 macrophages with an IC50 value of 6.6 ± 2.1 µM.
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Asunto principal:
Triterpenos
/
Medicamentos Herbarios Chinos
/
Gentianella
Idioma:
En
Revista:
J Nat Prod
Año:
2014
Tipo del documento:
Article