Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidates.
Chem Commun (Camb)
; 50(71): 10273-6, 2014 Sep 14.
Article
en En
| MEDLINE
| ID: mdl-25056269
ABSTRACT
We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Adyuvantes Inmunológicos
/
Mucina-1
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Vacunas contra el Cáncer
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Lipopéptidos
Idioma:
En
Revista:
Chem Commun (Camb)
Año:
2014
Tipo del documento:
Article
País de afiliación:
Australia