The effects of sesquiterpenes-rich extract of Alpinia oxyphylla Miq. on amyloid-ß-induced cognitive impairment and neuronal abnormalities in the cortex and hippocampus of mice.
Oxid Med Cell Longev
; 2014: 451802, 2014.
Article
en En
| MEDLINE
| ID: mdl-25180067
ABSTRACT
As a kind of medicine which can also be used as food, Alpinia oxyphylla Miq. has a long clinical history in China. A variety of studies demonstrated the significant neuroprotective activity effects of chloroform (CF) extract from the fruits of Alpinia oxyphylla. In order to further elucidate the possible mechanisms of CF extract which mainly contains sesquiterpenes with neuroprotection on the cognitive ability, mice were injected with Aß(1-42) and later with CF in this study. The results showed that the long-term treatment of CF enhanced the cognitive performances in behavior tests, increased activities of glutathione peroxidase (GSH-px) and decreased the level of malondialdehyde (MDA), acetylcholinesterase (AChE), and amyloid-ß (Aß), and reversed the activation of microglia, degeneration of neuronal acidophilia, and nuclear condensation in the cortex and hippocampus. These results demonstrate that CF ameliorates learning and memory deficits by attenuating oxidative stress and regulating the activation of microglia and degeneration of neuronal acidophilia to reinforce cholinergic functions.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
/
Corteza Cerebral
/
Alpinia
/
Hipocampo
Idioma:
En
Revista:
Oxid Med Cell Longev
Año:
2014
Tipo del documento:
Article
País de afiliación:
China