A direct interaction between the sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF®).

Balasuriya, Dilshan; D'Sa, Lauren; Talker, Ronel; Dupuis, Elodie; Maurin, Fabrice; Martin, Patrick; Borgese, Franck; Soriani, Olivier; Edwardson, J Michael

Balasuriya, Dilshan; D'Sa, Lauren; Talker, Ronel; Dupuis, Elodie; Maurin, Fabrice; Martin, Patrick; Borgese, Franck; Soriani, Olivier; Edwardson, J Michael.

Afiliación

Balasuriya D; Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom.
D'Sa L; Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom.
Talker R; Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom.
Dupuis E; CisBio Bioassays, Parc Marcel Boiteux BP 84175, 30200 Codolet, France, and.
Maurin F; CisBio Bioassays, Parc Marcel Boiteux BP 84175, 30200 Codolet, France, and.
Martin P; Institut de Biologie de Valrose (iBV), CNRS UMR 7277, INSERM U1091 UNS, Faculté des Sciences, Université de Nice Sophia Antipolis, 06108 Nice Cedex 2, France.
Borgese F; Institut de Biologie de Valrose (iBV), CNRS UMR 7277, INSERM U1091 UNS, Faculté des Sciences, Université de Nice Sophia Antipolis, 06108 Nice Cedex 2, France.
Soriani O; Institut de Biologie de Valrose (iBV), CNRS UMR 7277, INSERM U1091 UNS, Faculté des Sciences, Université de Nice Sophia Antipolis, 06108 Nice Cedex 2, France. Electronic address: olivier.soriani@unice.fr.
Edwardson JM; Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, United Kingdom,. Electronic address: jme1000@cam.ac.uk.

J Biol Chem ; 289(46): 32353-32363, 2014 Nov 14.

Article en En | MEDLINE | ID: mdl-25266722

Asunto(s)

Canales de Potasio Éter-A-Go-Go/metabolismo; Receptores sigma/metabolismo; Membrana Celular/metabolismo; Movimiento Celular; Colesterol/metabolismo; ADN Complementario/metabolismo; Canal de Potasio ERG1; Retículo Endoplásmico/metabolismo; Epítopos/metabolismo; Células HEK293; Humanos; Iones; Ligandos; Microscopía de Fuerza Atómica; Microscopía Fluorescente; Transfección; Receptor Sigma-1

Palabras clave

Atomic Force Microscopy (AFM); Fluorescence Resonance Energy Transfer (FRET); Molecular Imaging; Protein Complex; Sigma Receptor; hERG

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Receptores sigma / Canales de Potasio Éter-A-Go-Go Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article País de afiliación: Reino Unido

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