Downregulation of nitric oxide by electroacupuncture against hypoxicischemic brain damage in rats via nuclear factorκB/neuronal nitric oxide synthase.
Mol Med Rep
; 11(2): 837-42, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25374015
ABSTRACT
The present study aimed to investigate the role of nitric oxide (NO) against perinatal hypoxicischemic brain damage (HIBD) in rats by electroacupuncture (EA) and to examine its potential neuroprotective mechanism. NO content, the number of positive cells, neuronal nitric oxide synthase (nNOS) and nuclear factorκB (NFκB) in rat cortex cells were determined. The results demonstrated that treatment with EA significantly downregulated the NO content in the cortex cells (*P<0.05, **P<0.01, compared with the control groups) and alleviated cell damage in the cortex of rats with HIBD. The activator, SadenosylLmethionine and the inhibitor, hydroxylamine of cystathionineßsynthase (CBS), aggravated and remitted the hypoxic damage in the cortex cells, respectively. In addition, treatment with EA significantly downregulated the expression of nNOS and NFκB in the rat cortex cells (*P<0.05, **P<0.01, compared with the control groups). The results also indicated that treatment with EA downregulated the NO content of cortical cells against HIBD via the NFκB/nNOS pathway and further implied that the hydrogen sulfide/CBS system may be involved in the process. The present study provided a significant reference for the prevention and treatment of HIBD using the EA technique and also described a novel protective mechanism.
Texto completo:
1
Bases de datos:
MEDLINE
Medicinas Tradicionales:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapéuticos y Terapias MTCI:
Terapias_energeticas
Asunto principal:
FN-kappa B
/
Hipoxia-Isquemia Encefálica
/
Óxido Nítrico Sintasa de Tipo I
/
Óxido Nítrico
Idioma:
En
Revista:
Mol Med Rep
Año:
2015
Tipo del documento:
Article