Dietary fat increases vitamin D-3 absorption.
J Acad Nutr Diet
; 115(2): 225-230, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25441954
ABSTRACT
BACKGROUND:
The plasma 25-hydroxyvitamin D response to supplementation with vitamin D varies widely, but vitamin D absorption differences based on diet composition is poorly understood.OBJECTIVES:
We tested the hypotheses that absorption of vitamin D-3 is greater when the supplement is taken with a meal containing fat than with a fat-free meal and that absorption is greater when the fat in the meal has a higher monounsaturated-to-polyunsaturated fatty acid ratio (MUFAPUFA).DESIGN:
Open, three-group, single-dose vitamin D-3 comparative absorption experiment. PARTICIPANTS/SETTING:
Our 1-day study was conducted in 50 healthy older men and women who were randomly assigned to one of three meal groups fat-free meal, and a meal with 30% of calories as fat with a low (14) and one with a high (41) MUFAPUFA. After a 12-hour fast, all subjects took a single 50,000 IU vitamin D-3 supplement with their test breakfast meal. MAIN OUTCOMEMEASURES:
Plasma vitamin D-3 was measured by liquid chromatography-mass spectrometry before and 10, 12 (the expected peak), and 14 hours after the dose. STATISTICAL ANALYSES PERFORMED Means were compared with two-tailed t tests for independent samples. Group differences in vitamin D-3 absorption across the measurement time points were examined by analysis of variance with the repeated measures subcommand of the general linear models procedure.RESULTS:
The mean peak (12-hour) plasma vitamin D-3 level after the dose was 32% (95% CI 11% to 52%) greater in subjects consuming fat-containing compared with fat-free meals (P=0.003). Absorption did not differ significantly at any time point in the high and low MUFA and PUFA groups.CONCLUSIONS:
The presence of fat in a meal with which a vitamin D-3 supplement is taken significantly enhances absorption of the supplement, but the MUFAPUFA of the fat in that meal does not influence its absorption.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Grasas de la Dieta
/
Colecalciferol
/
Suplementos Dietéticos
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
Idioma:
En
Revista:
J Acad Nutr Diet
Año:
2015
Tipo del documento:
Article