An overview of tuberculosis plant-derived vaccines.
Expert Rev Vaccines
; 14(6): 877-89, 2015 Jun.
Article
en En
| MEDLINE
| ID: mdl-25683476
ABSTRACT
Tuberculosis (TB) is a leading fatal infectious disease to which the current BCG vaccine has a questionable efficacy in adults. Thus, the development of improved vaccines against TB is needed. In addition, decreasing the cost of vaccine formulations is required for broader vaccination coverage through global vaccination programs. In this regard, the use of plants as biofactories and delivery vehicles of TB vaccines has been researched over the last decade. These studies are systematically analyzed in the present review and placed in perspective. It is considered that substantial preclinical trials are still required to address improvements in expression levels as well as immunological data. Approaches for testing additional antigenic configurations with higher yields and improved immunogenic properties are also discussed.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Plantas Modificadas Genéticamente
/
Vacunas contra la Tuberculosis
Idioma:
En
Revista:
Expert Rev Vaccines
Año:
2015
Tipo del documento:
Article