Micronucleated erythrocytes in newborns of rat dams exposed to ultraviolet-A light during pregnancy; protection by ascorbic acid supplementation.
Mutat Res Genet Toxicol Environ Mutagen
; 782: 36-41, 2015 Apr.
Article
en En
| MEDLINE
| ID: mdl-25868130
ABSTRACT
Pregnant hairless rat dams were exposed to ultraviolet-A light (UVA) to induce micronucleated erythrocytes (MNE) in their fetuses. The control group was exposed to conventional light; the experimental groups were exposed to UVA (365nm) during gestational days 16-21. In some cases, ascorbic acid (Asc) was administered in the drinking water from gestational day 15 until delivery. Dams were sampled at 48-h intervals during gestation, from day 16 until delivery. Blood was also obtained from neonates at birth; MNE, micronucleated polychromatic erythrocytes (MNPCE), and polychromatic erythrocytes (PCE) were scored. Increased MNE and MNPCE were observed in neonates born to mothers exposed to UVA for 40, 80 or 160min, compared to the control group. Asc treatment reduced MNE and MNPCE induction.
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Bases de datos:
MEDLINE
Asunto principal:
Efectos Tardíos de la Exposición Prenatal
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Rayos Ultravioleta
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Micronúcleos con Defecto Cromosómico
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Eritrocitos
Idioma:
En
Revista:
Mutat Res Genet Toxicol Environ Mutagen
Año:
2015
Tipo del documento:
Article