Virtual Screening and Molecular Dynamics Simulations from a Bank of Molecules of the Amazon Region Against Functional NS3-4A Protease-Helicase Enzyme of Hepatitis C Virus.
Appl Biochem Biotechnol
; 176(6): 1709-21, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-26009474
ABSTRACT
Hepatitis C virus (HCV) infection is a disease that affects approximately 3% of the global population and requires new therapeutic agents without the inconvenience associated with current anti-HCV treatment. This paper reports on a study of a virtual screening and a molecular dynamics simulation of compounds derived from natural products from the Amazon region that are potentially effective against the NS3-4A enzyme of HCV, which plays an important role in the replication process of this virus. According to the results of the molecular docking calculations and subsequent consensual analysis, the best scored compounds showed interactions between hydrogen and residues of the catalytic triad as well as interactions with residues that guide ligands to the active site of the enzyme. They also showed stability in the molecular dynamics simulation, as the structures preserved important interactions at the active site of the enzyme. The root mean square deviation (RMSD) values were stabilized at the end of the simulation time. Such compounds are considered promising as novel therapies against HCV.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Antivirales
/
Inhibidores de Proteasas
/
Proteínas no Estructurales Virales
/
Hepacivirus
/
Simulación de Dinámica Molecular
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Appl Biochem Biotechnol
Año:
2015
Tipo del documento:
Article
País de afiliación:
Brasil