Supplementation with a blend of krill and salmon oil is associated with increased metabolic risk in overweight men.
Am J Clin Nutr
; 102(1): 49-57, 2015 Jul.
Article
en En
| MEDLINE
| ID: mdl-26016867
ABSTRACT
BACKGROUND:
Krill is an increasingly popular source of marine n-3 (ω-3) PUFA that is seen as a premium product. However, to our knowledge, the effect of krill-oil supplementation on insulin sensitivity in humans has not been reported.OBJECTIVE:
We assessed whether supplementation with a blend of krill and salmon (KS) oil [which is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] affects insulin sensitivity in overweight men.DESIGN:
The design was a randomized, double-blind, controlled crossover trial. A total of 47 men with a mean ± SD age of 46.5 ± 5.1 y, who were overweight [body mass index (in kg/m(2)) from 25 to 30] but otherwise healthy, received 5 1-g capsules of KS oil or a control (canola oil) for 8 wk and crossed over to another treatment after an 8-wk washout period. The primary outcome was insulin sensitivity assessed by using the Matsuda method from an oral-glucose-tolerance test. Secondary outcomes included lipid profiles, inflammatory markers, 24-h ambulatory blood pressure, and carotid artery intimamedia thickness.RESULTS:
Unexpectedly, insulin sensitivity (per the Matsuda index) was 14% lower with the KS oil than with the control oil (P = 0.049). A mediation analysis showed that, after controlling for the likely positive effects of blood EPA and DHA (i.e., the omega-3 index), the reduction in insulin sensitivity after KS-oil supplementation was more marked [27% lower than with the control oil (P = 0.009)].CONCLUSIONS:
Supplementation with a blend of KS oil is associated with decreased insulin sensitivity. Thus, krill-oil supplementation in overweight adults could exacerbate risk of diabetes and cardiovascular disease. This trial was prospectively registered at the Australian New Zealand Clinical Trials Registry as ACTRN12611000602921.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Resistencia a la Insulina
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Aceites de Pescado
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Suplementos Dietéticos
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Sobrepeso
Tipo de estudio:
Clinical_trials
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Etiology_studies
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Am J Clin Nutr
Año:
2015
Tipo del documento:
Article