Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis.

Kanhed, Ashish M; Sinha, Anshuman; Machhi, Jatin; Tripathi, Ashutosh; Parikh, Zalak S; Pillai, Prakash P; Giridhar, Rajani; Yadav, Mange Ram

Kanhed, Ashish M; Sinha, Anshuman; Machhi, Jatin; Tripathi, Ashutosh; Parikh, Zalak S; Pillai, Prakash P; Giridhar, Rajani; Yadav, Mange Ram.

Afiliación

Kanhed AM; Pharmacy Department, Faculty of Technology & Engineering, The M. S. University of Baroda, Vadodara 390001, Gujarat, India.
Sinha A; Pharmacy Department, Faculty of Technology & Engineering, The M. S. University of Baroda, Vadodara 390001, Gujarat, India.
Machhi J; Pharmacy Department, Faculty of Technology & Engineering, The M. S. University of Baroda, Vadodara 390001, Gujarat, India.
Tripathi A; Division of Neurobiology, Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara 390001, Gujarat, India.
Parikh ZS; Division of Neurobiology, Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara 390001, Gujarat, India.
Pillai PP; Division of Neurobiology, Department of Zoology, Faculty of Science, The M. S. University of Baroda, Vadodara 390001, Gujarat, India.
Giridhar R; Pharmacy Department, Faculty of Technology & Engineering, The M. S. University of Baroda, Vadodara 390001, Gujarat, India.
Yadav MR; Pharmacy Department, Faculty of Technology & Engineering, The M. S. University of Baroda, Vadodara 390001, Gujarat, India. Electronic address: mryadav11@yahoo.co.in.

Bioorg Chem ; 61: 7-12, 2015 Aug.

Article en En | MEDLINE | ID: mdl-26042530

Asunto(s)

Inhibidores de la Colinesterasa/síntesis química; Flavinas/química; Acetilcolinesterasa/química; Acetilcolinesterasa/metabolismo; Enfermedad de Alzheimer/tratamiento farmacológico; Enfermedad de Alzheimer/patología; Sitios de Unión; Butirilcolinesterasa/química; Butirilcolinesterasa/metabolismo; Línea Celular Tumoral; Supervivencia Celular/efectos de los fármacos; Inhibidores de la Colinesterasa/uso terapéutico; Inhibidores de la Colinesterasa/toxicidad; Evaluación Preclínica de Medicamentos; Flavinas/uso terapéutico; Flavinas/toxicidad; Humanos; Simulación del Acoplamiento Molecular; Estructura Terciaria de Proteína; Relación Estructura-Actividad

Palabras clave

Alzheimer's disease; Cholinesterase's inhibition; Cytotoxicity; Isoalloxazine; ß-Amyloid

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Inhibidores de la Colinesterasa / Flavinas Idioma: En Revista: Bioorg Chem Año: 2015 Tipo del documento: Article País de afiliación: India

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