Synthesis, characterization and biological evaluation of mixed-ligand ruthenium(II) complexes for photodynamic therapy.
Dalton Trans
; 44(39): 17335-45, 2015 Oct 21.
Article
en En
| MEDLINE
| ID: mdl-26387554
ABSTRACT
This study investigated the photodynamic therapy (PDT) and anticancer activity of mixed ligand Ru(ii) terpyridyl complexes (Ru1-Ru3). The photophysical and photochemical properties, hydrophobic properties, DNA binding and DNA transcription inhibition abilities, cell uptake efficiency, cellular localization and photo-cytotoxicity were investigated. Ru1-Ru3 exhibited red luminescence between 670-710 nm and functioned as photo-sensitizers (PSs) by generating both singlet oxygen and radical ions. Without light activation, Ru1-Ru3 were located at the cytoplasm and were nontoxic to cells. However, upon light activation, Ru1-Ru3 exhibited significant photocytotoxicity. After PDT treatment, mitochondria alteration and nuclear membrane disruption occurred, which resulted in relocalization of the complexes from the cytoplasm to the nucleus. Moreover, high cellular oxidative stress caused cell necrocytosis after PDT treatment.
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MEDLINE
Asunto principal:
Fotoquimioterapia
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Rutenio
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Fármacos Fotosensibilizantes
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Complejos de Coordinación
Idioma:
En
Revista:
Dalton Trans
Año:
2015
Tipo del documento:
Article