Central Nervous System Delivery of Intranasal Insulin: Mechanisms of Uptake and Effects on Cognition.
J Alzheimers Dis
; 47(3): 715-28, 2015.
Article
en En
| MEDLINE
| ID: mdl-26401706
ABSTRACT
Intranasal insulin has shown efficacy in patients with Alzheimer's disease (AD), but there are no preclinical studies determining whether or how it reaches the brain. Here, we showed that insulin applied at the level of the cribriform plate via the nasal route quickly distributed throughout the brain and reversed learning and memory deficits in an AD mouse model. Intranasal insulin entered the blood stream poorly and had no peripheral metabolic effects. Uptake into the brain from the cribriform plate was saturable, stimulated by PKC inhibition, and responded differently to cellular pathway inhibitors than did insulin transport at the blood-brain barrier. In summary, these results show intranasal delivery to be an effective way to deliver insulin to the brain.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cognición
/
Nootrópicos
/
Insulina
Idioma:
En
Revista:
J Alzheimers Dis
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos