A Mechanism-Based Approach to the Management of Osteoarthritis Pain.
Curr Osteoporos Rep
; 13(6): 399-406, 2015 Dec.
Article
en En
| MEDLINE
| ID: mdl-26419467
ABSTRACT
Pain from osteoarthritis (OA) affects millions of people worldwide, yet treatments are limited to acetaminophen, NSAIDs, physical therapy, and ultimately, surgery when there is significant disability. In recent years, our understanding of pain pathways in OA has developed considerably. Though joint damage and inflammation play a significant role in pain generation, it is now understood that both central and peripheral nervous system mechanisms exacerbate symptoms. Evolving management strategies for OA address central factors (e.g., sleep difficulties, catastrophizing, and depression) with treatments such as cognitive behavioral therapy and exercise. In addition, emerging data suggest that antibodies against peripheral signaling neuropeptides, such as nerve growth factor-1 (NGF-1), may significantly alleviate pain. However, concerns regarding potential adverse effects, such as rapidly progressive OA, still remain. A nuanced understanding is essential if we are to make headway in developing more effective treatments for OA.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Métodos Terapéuticos y Terapias MTCI:
Plantas_medicinales
Asunto principal:
Osteoartritis
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Terapia Cognitivo-Conductual
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Antiinflamatorios no Esteroideos
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Modalidades de Fisioterapia
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Catastrofización
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Manejo del Dolor
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Sensibilización del Sistema Nervioso Central
Idioma:
En
Revista:
Curr Osteoporos Rep
Año:
2015
Tipo del documento:
Article
País de afiliación:
Estados Unidos