Active Tuberculosis in HIV-Exposed Tanzanian Children up to 2 years of Age: Early-Life Nutrition, Multivitamin Supplementation and Other Potential Risk Factors.
J Trop Pediatr
; 62(1): 29-37, 2016 Feb.
Article
en En
| MEDLINE
| ID: mdl-26494727
ABSTRACT
BACKGROUND:
Over half a million children worldwide develop active tuberculosis (TB) each year. Early-life nutritional exposures have rarely been examined in relation to pediatric TB among HIV-exposed children. We therefore investigated independent associations of early-life nutritional exposures with active TB among HIV-exposed children up to 2 years of age.METHODS:
Participants were children from a randomized controlled multivitamin supplementation trial conducted in Dar es Salaam, Tanzania, from August 2004 to May 2008, who received daily multivitamin supplements or placebo for 24 months.RESULTS:
Lower mean corpuscular volumes [relative risks (RR) 0.48, 95% confidence interval (CI) 0.27, 0.87] and higher birth weights (RR 0.61, 95% CI 0.37, 0.99) were protective against active TB, whereas multivitamin supplementation was not associated with TB risk (RR 0.87, 95% CI 0.65, 1.16).CONCLUSIONS:
Knowledge of nutrition-related risk and protective factors for TB in HIV-exposed children could enhance preventive and case-finding activities in this population, contributing to efforts to reduce the global TB burden.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Tuberculosis Pulmonar
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Vitaminas
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Transmisión Vertical de Enfermedad Infecciosa
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Suplementos Dietéticos
Tipo de estudio:
Clinical_trials
/
Etiology_studies
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Risk_factors_studies
País/Región como asunto:
Africa
Idioma:
En
Revista:
J Trop Pediatr
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos